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KMID : 1143420220150241696
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Public Health Weekly Report
2022 Volume.15 No. 24 p.1696 ~ p.1702
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South American hemorrhagic fevers: characteristics, vaccines, and treatment
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No Jin-Sun
Choi Myung-Min
Yi Hwa-Jung
Rhie Gi-Eun
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Abstract
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South American hemorrhagic fevers (SAHF) are, acute febrile hemorrhagic diseases and zoonoses present in South America. SAHF are caused by 5 Mammarenaviruses (J unin, Chapare, Sabia, Machupo, and Guanarito virus). Transmission to humans occurs through direct contact with infected rodents and inhalation of the virus in their aerosolized excreta. In spite of the high fatality rate of SAHF, currently only Junin virus, the etiological agent of Argentine hemorrhagic fever, has a licensed preventive vaccine (Candid #1) which is made of a live-attenuated Junin virus. There is no commercialized treatments specific to SAHF, and symptomatic treatments for the SAHF are used. Therefore, it is important and essential to reduce the opportunity of infection by avoiding contact with infected rodents and by complying with infection prevention and control procedures while visiting endemic areas.
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KEYWORD
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South American hemorrhagic fevers, Vaccines, Treatment
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